e(ye)BRAIN

SERGE KINKINGNEHUN, PhD
Founder, CEO and Scientific Director

Serge Kinkingnéhun has a doctorate in digital imaging from the Ecole des Mines in Saint-Etienne, France, specializing in medical imaging, and a B.S. in biochemistry from Florida Tech (USA). He also pursued a Master's Degree in cognitive science at the UPMC in Paris. Serge conducted a 7-year research project on early detection of Alzheimer's disease through MRI at Professor Dubois' Inserm unit at Pitié-Salpêtrière Hospital in Paris. At the same time he spent 8 years developing tools to create cognitive neuropsychology protocols for various research laboratories. He has published several articles in scientific journals.

Serge founded e(ye)BRAIN in 2008, with the goal of utilizing his research results to help patients. He has received several awards for this achievement and was chosen for training in start-up management at the HEC (a prestigious French business school).

Contact
e.mail : serge@eye-brain.com
tel : +33 1 83 64 37 38

Research
Serge's research projects focus on diagnosing brain diseases. His general approach is to develop functional neuroimaging techniques, applications for neuropsychological testing, and eye movement analysis, and adapt them for healthy patients as well as those suffering from neurological or psychiatric diseases.

Publications

Patents
Frédéric Bernert, Mickael Maillard, Serge Kinkingnéhun, e(ye)BRAIN, Système optique de suivi de mouvements oculaires et dispositif support associé, dépôt INPI n° 1052720, du 9/04/2010.

B. Oliveiro, M. Thiebaut de Schotten, P. Bartolomeo, S. Kinkingnéhun, e(ye)BRAIN, Système de détection in vivo d'une zone fonctionnelle du cerveau humain entraînant en cas de lésion un syndrome de négligence spatiale unilatérale, date de dépôt INPI : le 26/05/2009, N° de dépôt: 09 53463.

S. Kinkingnéhun, M. Maillard, M. Argudo, e(ye)BRAIN, Procédé et système de détection d'anomalies oculomotrices, date de dépôt INPI : le 01/04/2009, N° de dépôt : 09 52102.

EBO 07290604.3, "Method for analysing an image of the brain of a subject, computer program product for analysing such image and apparatus for implementing the method", 2007

Articles in Scientific Journals
M. Sarazin, V. Chauviré, E. Gerardin, O. Colliot, S. Kinkingnéhun, L.C. de Souza, L. Hugonot-Diener, L. Garnero, S. Lehéricy, M. Chupin, et B. Dubois, “The Amnestic Syndrome of Hippocampal type in Alzheimer's Disease: An MRI Study,” Journal of Alzheimer's Disease: JAD, Aoû. 2010.

L. Mesrob, B. Magnin, O. Colliot, M. Sarazin, V. Hahn-Barma, B. Dubois, P. Gallinari, S. Lehericy, S. Kinkingnehun and H. Benali, "Identification of atrophy patterns in Alzheimer's disease based on SVM feature selection and anatomical parcellation", Annals of the BMVA 2009 (7), 1-9.

L. Bergouignan, M. Chupin, Y. Czechowska, S. Kinkingnéhun, C. Lemogne, G. Le Bastard, M. Lepage, L. Garnero, O. Colliot, et P. Fossati, “Can voxel based morphometry, manual segmentation and automated segmentation equally detect hippocampal volume differences in acute depression?,” NeuroImage, vol. 45, Mar. 2009, pp. 29-37.

Magnin B, Mesrob L, Kinkingnehun S, Pelegrini-Issac M, Colliot O, Sarazin M, et al. Support vector machine-based classification of Alzheimer's disease from whole-brain anatomical MRI. Neuroradiology 2009; 51(2):73-83.

Thiebaut de Schotten M., Kinkingnéhun S., Delmaire C., Lehéricy S., Duffau H., Thivard L., Volle E., Levy R., Dubois B. and Bartolomeo P. Visualization of disconnection syndromes in humans. Cortex 2008; 44(8):1097-1103.

Volle, E., Kinkingnéhun, S., Pochon, J.B., Mondon, K., Thiebaut de Schotten, M., Seassau, M., Duffau, H., Samson, Y., Dubois, B., Levy, R. The Functional Architecture of the Left Posterior and Lateral Prefrontal Cortex in Humans. Cereb Cortex 2008; 18(10):2460-9.

Kinkingnéhun, S., Sarazin, M., Lehéricy, S., Guichart-Gomez, E., Hergueta, T., Dubois, B. VBM anticipates the rate of progression of Alzheimer disease. A 3-year longitudinal study. Neurology 2008; 70(23):2201-11.

Kinkingnéhun S., Volle E., Pélégrini-Issac M., Golmard J.-L., Lehéricy S., du Boisgueheneuc F., Zhang-Nunes S., Sosson D., Duffau H., Samson Y., Levy R. and Dubois B. A novel approach to clinical-radiological correlations: Anatomo-Clinical Overlapping Maps (AnaCOM): Method and validation. Neuroimage 2007;37(4):1237-1249.

Chupin M., Mukuna-Bantumbakulu A. R., Hasboun D., Bardinet E., Baillet S., Kinkingnehun S., Lemieux L., Dubois B. and Garnero L. Anatomically constrained region deformation for the automated segmentation of the hippocampus and the amygdala: Method and validation on controls and patients with Alzheimer's disease. Neuroimage 2007;34(3):996-1019.

Lehericy S., Marjanska M., Mesrob L., Sarazin M. and Kinkingnehun S. Magnetic resonance imaging of Alzheimer's disease. Eur Radiol 2007;17(2):347-362.

du Boisgueheneuc F., Levy R., Volle E., Seassau M., Duffau H., Kinkingnehun S., Samson Y., Zhang S. and Dubois B. Functions of the left superior frontal gyrus in humans: a lesion study. Brain 2006;129(Pt 12):3315-3328.

Barillot C., Benali H., Dojat M., Gaignard A., Gibaud B., Kinkingnehun S., Matsumoto J. P., Pelegrini-Issac M., Simon E. and Temal L. Federating Distributed and Heterogeneous Information Sources in Neuroimaging: The NeuroBase Project. Stud Health Technol Inform 2006;120:3-13.

Thesis
S.R. Kinkingnéhun, "Traitement des reconstructions angiographiques tridimensionnelles et détection de malformations d'arbres artériels intracrâniens", Thèse de doctorat de l'Ecole des Mines de Saint-Étienne, 235 ID, spécialité Images informatiques, 170 pages, Saint-Étienne, 2001.(pdf)

Articles de conferences
Chupin, M., D. Hasboun, R. Mukuna-Bantumbakulu, E. Bardinet, S. Baillet, S. Kinkingnéhun, L. Lemieux, B. Dubois, and L. Garnero. 2006. Competitive Segmentation of the Hippocampus and the Amygdala from MRI data: Validation on Young Healthy Controls and Alzheimer's Disease Patients in A. M. Emir A. Amini, ed. Medical Imaging'06. SPIE, San Diego, CA.

Barillot, C., Benali, H., Dojat, M., Gaignard, A., Gibaud, B., Kinkingnéhun, S., Matsumoto, J.-P., Pélégrini-Issac, M., Simon, E., Temal, L., 2006. Federating distributed and heterogeneous information sources in neuroimaging: the NeuroBase project. In: HealthGrid 2006.

Barillot, C., R. Valabregue, J. Matsumoto, F. Aubry, H. Benali, Y. Cointepas, O. Dameron, M. Dojat, E. Duchesnay, G. Gibaud, S. Kinkingnéhun, D. Papadopoulos, M. Pélégrini-Issac, and E. Simon. 2004. NeuroBase : Management of Distributed and Heterogeneous Information Sources in Neuroimaging. Workshop on DIstributed DAtabases and processing in Medical Image Computing (DIDAMIC'04), Rennes, France.

Gibaud, B., M. Dojat, F. Aubry, H. Benali, O. Dameron, S. Kinkingnéhun, J. Matsumoto, M. Pélégrini-Issac, R. Valabregue, and C. Barillot. 2004. Toward an ontology for sharing neuroimaging data and processing methods: experience learned from the development of a demonstrator. Workshop on DIstributed DAtabases and processing in Medical Image Computing (DIDAMIC'04), Rennes, France.

S. R. Kinkingnéhun, F. du Boisguéheneuc, J.-L. Golmard, S. X. Zhang, R. Levy and B. Dubois, "Anatomoclinical overlapping maps (AnaCOM): a new method to create anatomo-functional maps from neuropsychological tests and structural MRI scan of subjects with brain lesions," Medical Imaging'04, A. M. Emir A. Amini, 5369, 583-592, San Diego, CA, 2004.

S.R. Kinkingnéhun, F. Poupon, and J.-F. Mangin, "Squelettisation homotopique avec montées des eaux. Application à la squelettisation d'arbres artériels.," présenté aux 8ème Journées de l'Association Française d'Informatique Graphique (AFIG 2000), pp. 253-262, Grenoble, France, 2000.

S.R. Kinkingnéhun, M. Frudit, A. Casasco, J. Blanc-Talon, C. Marsault, and B. Peroche, "Segmentation of Arteries in 2D B-Spline Multiscale Mode," presented at Advanced Concepts for Intelligent Vision Systems (Proceedings of), pp. 59-64, Baden-Baden, Allemagne, 2000.

S.R. Kinkingnéhun, E. Vivas-Diaz, J. Blanc-Talon, C. Marsault, and B. Peroche, "3D B-Spline Smoothing," presented at Advanced Concepts for Intelligent Vision Systems (Proceedings of), pp. 40-44, Baden-Baden, Allemagne, 1999.

Conferences
Kinkingnéhun, S., Sarazin, M., Picard, G., Guichard-Gomez, E., Thivard, L., Lehéricy, S., Dubois, B., 2006. MRI Atrophy at Baseline in Alzheimer's Disease Differentiates Fast and Slow Decliners Better Than Neuropsychology: a 3-Year Longitudinal Study. In: ICAD2006, The 10th International Conference on Alzheimer's Disease and Related Disorders, Madrid, Spain, July 15-20, pp. 65-66.

Mukuna-Bantumbakulu, R., Chupin, M., Kinkingnéhun, S., Hasboun, D., Dormont, D., Garnero, L., Dubois, B., 2006. Automated Volumetry of the Amygdala and the Hippocampus in Alzheimer's Disease. In: ICAD2006, The 10th Internation Conference on Alzheimer's Disease and Related Disorders, Madrid, Spain, July 15-20, p. 346.

Kinkingnéhun, S., Volle, E., Golmard, J.-L., Lehéricy, S., du Boisguéheneuc, F., Zhang, S., Duffau, H., Samson, Y., Levy, R., Dubois, B., 2006. Anatomo-Clinical Overlapping Maps (AnaCOM): Method and Validation. In: HBM, Florence.

Volle, E., Levy, R., Kinkingnéhun, S., du Boisgueheneuc, F., Duffau, H., Samson, Y., Golmard, J.-L., Dubois, B., 2006. Neural basis of the organization of prefrontal functions in humans assessed by a voxel-by-voxel lesion mapping study in patients with prefrontal lesions. In: HBM, Florence.

Thiebaut de Schotten, M., Kinkingnéhun, S., Delmaire, C., Levy, R., Volle, E., Lehéricy, S., Duffau, H., Dubois, B., Bartolomeo, P., 2006. OVER-TRACK: a new tool to visualize the white matter organization in Talairach. In: HBM, Florence.

Barillot, C., Benali, H., Dojat, M., Gaignard, A., Gibaud, B., Kinkingnéhun, S., Matsumoto, J.-P., Pélégrini-Issac, M., Simon, E., Temal, L., 2006. Federating Distributed and Heterogeneous Information Sources in Neuroimaging: The NeuroBase Project. In: HBM.

Kinkingnéhun, S., Sarazin, M., Picard, G., Guichard-Gomez, E., Hergueta, T., Thivard, L., Lehéricy, S., Dubois, B., 2006. L'atrophie IRM dans la maladie d'Alzheimer prédit mieux le déclin cognitif que la neuropsychologie - Une étude longitudinale de 3 ans. In: Journées de Neurologies de Langue Française, Toulouse, 12-15 avril 2006, p. 20.

Kinkingnéhun, S., M. Sarazin, G. Picard, E. Guichard-Gomez, T. Hergueta, L. Thivard, S. Lehéricy, and B. Dubois. 2006. MRI atrophy predicts cognitive decline in AD better than neuropsychology : a 3-year longitudinal study. American Academy of Neurology, San Diego, CA.

Hugonot-Diener, L., M. Sarazin, S. Kinkingnéhun, E. Guichart-Gomez, S. Lehéricy, and B. Dubois. 2006. Relationships between Regional Cortical Atrophy and cognitive performance in early AD patients: a VBM study. Amercian Academy of Neurology, San Diego, CA.
Bonnet, D., S. Kinkingnéhun, J.-M. Villapando, V. Hahn-Barma, S. Lehéricy, and B. Dubois. 2006. Neural correlates of episodic encoding and delayed retrieval impairment in Alzheimer's disease: an fMRI study. American Academy of Neurology, San Diego, CA.

Kinkingnéhun, S., L. Thivard, S. Lehéricy, G. Picard, L. Hugonot-Diener, M. Sarazin, G. Dalla Barba, and B. Dubois. 2005. Déclineurs rapides et déclineurs lents : intérêt de l'étude en VBM dans la maladie d'Alzheimer. 8ème Réunion Francophone sur la Maladie d'Alzheimer et les syndromes apparentés, Saint-Etienne, France.

Hugonot-Diener, L., M. Sarazin, S. Kinkingnéhun, E. Guichard, T. Herguetta, M. Volteau, G. Dalla Barba, and B. Dubois. 2005. Corrélations anatomo-fonctionnelles chez des malades d'Alzheimer (MA): entre Voxel- based morphometry (VBM) et tests psychométriques. 8ème Réunion Francophone sur la Maladie d'Alzheimer et les syndromes apparentés, Saint-Etienne, France.

Bonnet, D., S. Kinkingnéhun, J.-M. Villapando, V. Hahn-Barma, S. Lehéricy, and B. Dubois. 2005. Etude en IRMf des réseaux d'activations cérébrales de la mémoire épisodique chez des patients atteints de la maladie d'Alzheimer au stade débutant. 8ème Réunion Francophone sur la Maladie d'Alzheimer et les syndromes apparentés, Saint-Etienne, France.

Kinkingnéhun, S. 2005. Approche IRM multi-modale de la Maladie d'Alzheimer : vers un diagnostic IRM ? in H. Chainay, ed. Vieillissement normal et pathologique : mémoire. Université de Brest, Brest, France.

Kinkingnéhun, S. R. J. 2005. Approche IRM multi-modale de la Maladie d'Alzheimer : vers un diagnostic IRM ? Journal de Radiologie.

Gibaud, B., Dojat, M., Temal, L., Aubry, F., Benali, H., Dameron, O., Kinkingnéhun, S., Matsumoto, J.-P., Pélégrini-Issac, M., Valabregue, R., Barillot, C., 2005. NeuroBase: gestion de données et de connaissances distribuées en neuroimagerie. In: Journée spéciale du GDR STIC Santé-Inserm sur : Gestion de données et de traitements distribués en imagerie médicale.

Dubois, B., M. Chupin, S. Kinkingnéhun, E. Guichart, M. Kalafat, and L. Garnero. 2005. Les outils du diagnostic de la maladie d’Alzheimer au stade pré-démentiel. Journée annuelle extraordinaire de la Société Française de Neurologie, Paris, France.

S. R. J. Kinkingnéhun, L. Thivard, S. Lehéricy, M. Sarazin, and B. Dubois, "Longitudinal voxel based morphometry analysis of Alzheimer's disease," presented at FENS, Lisbonne, Portugal, 2004.

M. Chupin, D. Hasboun, S. Baillet, S. Kinkingnéhun, B. Dubois, and L. Garnero, "Competitve segmentation of the hippocampus and the amygdala. Volumetry in Alzheimer's disease," HBM 2004, sous presse, Budapest, Hongrie, 2004

F. du Boisguéheneuc, S. R. Kinkingnéhun, H. Duffau, L. Capelle, S. X. Zhang, B. Dubois, and R. Levy, "Le rôle du gyrus frontal supérieur dans la mémoire de travail : étude à l'aide d'ANACOM, une nouvelle méthode de corrélation anatomo-clinique," presented at JNLF, Strasbourg, France, 2004.

S. R. J. Kinkingnéhun, L. Thivard, S. Lehéricy, M. Sarazin, and B. Dubois, "Etude longitudinale en voxel based morphometry dans la maladie d'Alzheimer," JNLF, sous presse, Strasbourg, France, 2004

J.-M. Villalpando, S. Kinkingnéhun, S. Lehéricy, V. Hahn-Barma, G. Dalla Barba, and B. Dubois, "Réseau d'activation en IRM fonctionnelle de la mémoire épisodique visuelle à long terme et mémoire de travail chez le sujet âgé," Alzheimer 2003 - 7éme réunion francophone sur la maladie d'Alzheimer et les syndromes apparentés, Paris, France, 2003

C. Barillot, L. Amsaleg, F. Aubry, J.P. Bazin, H. Benali, Y. Cointepas, I. Corouge, O. Dameron, M. Dojat, C. Garbay, B Gibaud, P. Gros, S. Kinkingnéhun, G. Malandain, J-P. Matsumoto, D. Papadopoulos, M. Pélégrini, N. Richard, E. Simon, "NeuroBase : Management of Distributed Knowledge and Data Bases in Neuroimaging", HBM 2003, New York, USA, 2003.

Barillot, C., L. Amsaleg, F. Aubry, J. Bazin, H. Benali, Y. Cointepas, I. Corouge, O. Dameron, M. Dojat, C. Garbay, B. Gibaud, P. Gros, S. Kinkingnéhun, G. Malandain, J. Matsumoto, D. Papadopoulos, M. Pélégrini, N. Richard, and E. Simon. 2003. Neurobase : Gestion de données et de connaissances distribuées en Neuroimagerie. Journée Web semantique, Rennes, France.

S. Lopez, S. Kinkingnéhun, F. Morizot, and E. Tschachler, "Use of Digital Photography Assessed by Image Analysis to Measure Skin Surface Properties," presented at Proceedings of the 13th International Congress of the International Society of Bioengineering and Skin, pp. 71, Jerusalem, Israël, 2000.

E. Vivas-Diaz, A. Casasco, L. Paul-Diaz, A. Biondi, N. Sourour, R. Pacheco, S. Kinkingnéhun, and C. Marsault, "Utilidad de la Angiografia Rotacional 3D por Cateterismo en el Diagnostico y Tratamiento de los Aneurismas Intracraniales,", La Coruna (Galicia, Espana), 1999.