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PRODUCTS |
PARKINSONIAN SYNDROMES OCULOMOTRICITY IN PARKINSONIAN SYNDROMES PATIENTS WITH PARKINSONIAN SYNDROMES PRESENT SPECIFIC PATTERNS OF ABNORMAL EYE MOVEMENTS
 SND: Striatonigral Degeneration; CBD: Corticobasal Degeneration; PSP: Progressive Supranuclear Palsy, N: normal; Lat.: latency; Acc.: accuracy; Sacc.: saccade. Green: discriminating factors. By taking these oculomotor symptoms patterns into account, the Mobile EBT® reliably and significantly improve early syndrome discrimination. This in turn: • Helps patients and caretakers cope with the disease • Facilitates disease-management and monitoring • Improves the quality of clinical trials data by helping determining homogeneous patients groups OCULOMETRIC CLINICAL EXAMINATION CAN REVEAL TWO TYPES OF EYE-MOVEMENT DISORDERS: • Distinctive criteria (DC): disorders that are highly correlated to a specific disease • Confirmatory criteria (CC): disorders that are generic of neurological dysfunction To give a sense of this distinction, criteria are listed below for the case of Progressive Supranuclear Palsy (PSP), the most frequent non-idiopathic parkinsonian syndrome : DC: PSP-SPECIFIC OCULOMOTOR IMPAIRMENTS: • Slower vertical saccades (latency and speed) • Asymmetry in the speed of up/down vertical saccades • Presence of square waves during fixation and anti-saccades tasks • High rate of errors in anti-saccades tasks CC: GENERIC IMPAIRMENTS FOUND IN PSP PATIENTS: During horizontal visually guided saccades: • Irregular trace and instable inter-saccades • Hypometric saccades (gain << 0.92) • Longer latencies  Abnormalities in PSP Patient eye movements |
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